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In 2010, ONT combined two technologies addressing each of the main outstanding problems. The first was an engineered nanopore developed in collaboration with Bayley’s lab that could discriminate between individual DNA bases, solving the resolution issue. The second was a trick to slow the DNA down to detectable speeds, using the familiar DNA polymerase enzyme. Mark Akeson’s lab at UC Santa Cruz had identified a specific polymerase from the bacterial virus ɸ29 that replicated DNA at an ideal speed for detection via nanopore. Template DNA strands were replicated just before entering the nanopore, passing through slowly enough for individual bases’ effect on the electrical current to be detectable and allowing the DNA sequence to be read one base at a time.
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为了解决精度问题，华为这次带来的是一套一体双焦的双光路架构。简单来讲，他们在一个雷达的壳子里，塞进了广角和长焦两个独立的接收单元。
这种规模的投资远超经济产出——这不是普通的预算问题，而是结构性回报难题。这就是AI基础设施的“投资悖论”：超大规模云服务商们陷入了典型的“囚徒困境”——没有人敢停止投资，因为担心失去竞争优势；但持续加码投资，又在不断摧毁股东价值。
Neither the instructions for authors from 2010 — when Koren and his coauthor Michael Rieder would have written their article — nor the linked list of article types — state the cases are fictionalized, or fictional. A set of instructions dated 2015, and linked from the journal’s author guidelines, indicate the “clinical vignette” should “describe a fictional case.”